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Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

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The GLP-1R is expressed in many tissues, including pancreatic islets, the central nervous system, lung, kidney, heart, intestine, and also on immune cells ( When secreted by L cells, GLP-1 either functions in an endocrine manner, being released into the blood stream where it is rapidly inactivated by DPP-4 with a half-life of about 2 min, or exerts paracrine effects like stimulating neurons

Above 24 hours or any exposure to heat over 86F (30C): call your pharmacy and ask